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Quality of Life Improvement: Lastly, tirzepatide can significantly improve the quality of life for individuals with obesity and type 2 diabetes by reducing symptoms, such as fatigue, thirst, and frequent urination, associated with uncontrolled hyperglycemia

It explains these establish a starting point for tracking response and inform safety decisions later

It is effective in reducing glycated hemoglobin levels in patients with type 2 diabetes by reducing fasting and postprandial blood sugar levels

Whether those effects run through GHIGF-1 signaling, direct GHSR-1a activation in cardiomyocytes, or some combination remains an active question