This compromised barrier function facilitates bacterial translocation while recruiting and activating pro-inflammatory immune cells, such as neutrophils and Th17 cells, thereby intensifying the inflammatory process (180)
We clustered 94% of the ATLAS participants into one of the five 1000 Genome superpopulation (African (AFR), admixed American (AMR), East Asian (EAS), European (EUR), Middle Eastern (MID), South Asian (SAS)) while the remaining individuals ancestry could not be ascertained
Translationally speaking, this signifies that CNS-selective targeting, or avoidance, coupled with the signaling profile, could help tailor GLP-1RAs for specific diseases, patient subgroups, or tolerability profiles
In functional medicine, individualized treatment plans are paramount