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Clinically significant portal hypertension events were defined as the first occurrence of esophageal varices (i.e., with and without bleeding), gastric varices, ascites, hepatic failure, hepatorenal syndrome, portal hypertension, liver transplant status, fibrosis and cirrhosis of liver, hepatic encephalopathy, jaundice, and chronic passive congestion of liver

This applies even if you have previously used another GLP-1 medication, such as Mounjaro or Liraglutide

This study adhered to the principles of the Declaration of Helsinki and was approved by the Ethics Committee of Anzhen Hospital, Capital Medical University

Blood 115 , 453474 (2010)