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However, when the drug is taken in an overdose, the Uridine diphosphate-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) in the human liver that participate in APAP detoxification become saturated, and a considerable proportion of this drug is activated by human CYPs (primarily CYP2E1)

Animal data is a necessary first step, but its far from sufficient on its own to draw conclusions about a drugs effectiveness and safety in humans

Micro-batched and PEDS activated within 24-72 hours of dispatch to ensure peak molecular integrity

Thus, research interest has focused on the development of early detection techniques via monitoring saliva, serum, CSF, neuroimaging biomarkers, and cognitive dysfunction [31]