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Then in an announcement on Tuesday, the drugmaker unveiled that the National Medical Products Administration (NMPA), Chinas top drug regulator, had allowed the injection to be used in weight reduction, making it the first GLP-1 receptor agonist officially available in the country for people who wish to lose weight but for diabetes-unrelated reasons

Vittorelli A, Gauthier C, Michoudet C, Baverel G: Metabolic viability and pharmaco-toxicological reactivity of cryopreserved human precision-cut renal cortical slices

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Mechanistically, a microglial inflammation-oxidative stress feedforward loop perpetuates injury: Activated microglia secrete neurotoxins, impairing neuronal mitochondrial function and antioxidant capacity (such as GPX4), thus increasing ROS leakage