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Patients with a history of recent IgE-mediated (allergic or anaphylactic) reaction should empirically avoid all antimicrobial sulfonamides based on the risk of cross-reaction

Side Effects and Safety Most common adverse effects include: Blue or green discoloration of urine and skin Nausea, vomiting, dizziness Confusion or serotonin syndrome (especially if combined with SSRIs) Hemolysis in patients with G6PD deficiency (contraindicated) It is generally well tolerated at low doses, but IV administration requires careful dosing due to risks of neurotoxicity and cardiac events at higher levels

Borbe JBC, Elvambuena BF, Eugenio FAD, Tan RJM

Abbreviations Author Contributions Conceptualization, A.A