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TNF- inhibitors such as Infliximab and Etanercept did not show benefits in chronic heart failure due to the worsening of the clinical status and some serious adverse effects, such as upper respiratory tract infections [18, 19]

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This provides a theoretical basis for uncertainty management, serving as a crucial caveat for clinicians: when utilizing GLP-1RAs, one must distinguish between the relative certainty of metabolic benefits and the stochastic nature of reproductive improvements

Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle