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In patients with type 2 DM, GLP-1R agonists have demonstrated a reduction in circumferential strain and improvement in markers of diastolic function, a key component of diabetic cardiomyopathy and the risk of developing heart failure

Total neoadjuvant treatment with short-course radiotherapy followed by sintilimab plus capecitabine-oxaliplatin versus short-course radiotherapy followed by capecitabine-oxaliplatin in patients with locally advanced rectal cancer (SPRING-01): a single-centre, open-label, phase 2, randomised controlled trial