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Understanding these nuances can empower patients to communicate effectively with their healthcare team, ensuring a tailored approach to their treatment plan that minimizes discomfort while maximizing therapeutic benefits

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Seek urgent medical advice if you experience: Severe or persistent low mood lasting more than two weeks Thoughts of self-harm or suicide contact your GP immediately, call NHS 111, attend A&E, or call 999 if you are in immediate danger Significant anxiety or panic attacks that interfere with daily functioning Marked personality changes or behaviour that concerns you or your family Symptoms of severe depression , including loss of interest in activities, feelings of worthlessness, or inability to function For immediate support, you can also contact the Samaritans (116 123) or your local NHS urgent mental health helpline

doi: 10.1111/exd.13887