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A large Cochrane review noted that many of the positive studies had methodological limitations, and not all trials found significant benefits. It's also worth knowing that some prominent DHEA researchers have disclosed commercial interests in DHEA supplementation, which is important context when weighing the evidence

However, if you have a history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, this treatment may not be suitable for you

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