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The menstrual irregularities and absence of ovulation caused by polycystic ovary syndrome can contribute to difficulty becoming pregnant

On the basis of the ability of GLP-1RA/tesaglitazar to induce neuronal activation in the hypothalamus, and recent data indicating that PPAR might affect systemic energy metabolism via hypothalamic neurocircuitries 5,6 , we next assessed the response of the hypothalamic proteome of DIO mice 10 h after single peripheral (s.c.) drug treatment using liquid chromatographymass spectrometry (LCMS)