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Chronic inflammatory cytokines like interleukin-6 and tumor necrosis factor-alpha can suppress ovarian steroidogenesis by decreasing enzyme activity necessary to produce estrogen and progesterone

This can be both sobering and encouraging

The water shift stabilizes quickly, and the underlying fat loss from the medication continues underneath it

Patients typically exhibit symmetric, progressive muscle weakness and atrophy, ultimately leading to premature death due to respiratory and cardiovascular complications