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Cells on poly-D-lysine-coated coverslips were loaded with 2 M Fura-2 AM (Thermo Fisher Scientific, Waltham, MA) at 37 C for 40 min in DMEM

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To put that into perspective, someone who started the trial at 300 pounds could theoretically lose about 60 pounds on tirzepatide versus roughly 41 pounds on semaglutide over about a year and four months

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