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2 Materials and methods 2.1 Sample collection and demographics Urine samples were collected between 2015 and 2018 under established protocols (Bi et al., 2020) by the Desmond Tutu HIV Foundation and the South African Tuberculosis Vaccine Initiative (SATVI) at the University of Cape Town (UCT)

1,2 Associated increases in dopamine and serotonin may underlie ketamines antidepressant feel good effects but also may hold potential for ketamine addiction

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The distinction between "injection day" and "day seven" becomes less dramatic over time, though most people still notice a pattern of stronger effects in the first 48 hours after each dose