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Drug Interaction Studies JANUMET XR Coadministration of multiple doses of sitagliptin (50 mg) and metformin HCl (1000 mg) given twice daily did not meaningfully alter the pharmacokinetics of either sitagliptin or metformin in patients with type 2 diabetes

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In this group, not only lipid-lowering therapy is important (in these patients, lipid disorders may occur as often as in general population), but particular attention should be paid to possible drug interactions, especially as these patients often receive multiple concomitant medications

(2023) 37:e5698