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Inflammation-targeting peptides may complement probiotic therapy by addressing the inflammatory component of gut dysfunction, while KPV peptide has shown specific promise for intestinal inflammation in preclinical research

Since we cannot prove a positive effect of gastrointestinal adverse effects on efficacy, should we consider sparing patients such suffering

Several things can reduce this signal: 1

Currently, the targeting objects of these multifunctional drug delivery nanoplatforms are mainly focused on the inflammatory microenvironment of arthritis (such as infiltrating M1-type macrophages and TNF-) and FLS, aiming to eliminate the adverse effects of these factors [52,53,54]