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10.1136/bmjopen-2016-013543 71

Niche stiffening compromises hair follicle stem cell potential during aging by reducing bivalent promoter accessibility

Semaglutide's adverse event profile is well-documented: gastrointestinal side effects (nausea, vomiting, diarrhoea) in 3045% of patients during dose titration, typically resolving within 48 weeks

The researchers noted that compared with the control group, the epithalamin-treated patients exhibited [10]: Decelerated aging of the cardiovascular system Decreased rate of cardiovascular mortality and cardiovascular failure (-50%) Less age-associated impairment of physical endurance Normalized circadian rhythm for melatonin production Normalized circadian rhythm for lipid (fats) and carbohydrate metabolism Lower rate of mortality (-28%) The follow-up study on long-term epithalamin treatment represents strong evidence of eptithalons favorable safety profile and relative absence of notable epithalon side effects