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For patients battling dysautonomia and POTS, L-theanine acts as a natural "autonomic depressant," gently guiding the nervous system out of "fight or flight" and back into "rest and digest." By enhancing GABA and blocking glutamate, L-theanine directly dampens the overactivity of the sympathetic nervous system

[DOI] [PubMed] [Google Scholar] 52.Spencer JR, Torrado T, Sanchez RS, Vaughan ED, Jr, Imperato-McGinley J

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However, when very high oral doses are taken, approximately 1% can be absorbed through passive diffusion, independent of intrinsic factor, which explains how mega-doses can still raise serum levels