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As shown in Figure 4C, these effects may be mediated by increased glutamatergic signaling from the ventral hippocampus to the NAc since microinjection of ghrelin into the ventral hippocampus increased phosphorylated tyrosine hydroxylase in the NAc, suggesting increased dopamine release (Kanoski et al., 2013)

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The rats receiving GABA therapy (PPA-GABA group) exhibited degenerative changes and reduced neuron density in the CA4 region, similar to PPA-treated group (Figure 3E)