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Specifically, the proportion of Firmicutes is markedly reduced, the Bacteroidetes-to-Firmicutes ratio is decreased, and the abundance of Acidobacteria is increased (Dan et al., 2020

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59,60 Specific genes implicated include vascular endothelial growth factor (VEGF), neurotrophic receptor tyrosine kinase 1, sodium voltage-gated channel alpha subunit 2 (SCN2A), angiotensin-converting enzyme, and methylenetetrahydrofolate reductase, with polymorphisms associated with increased DN susceptibility

This is needed to detoxify and protect cells from damage