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Combined sodium-glucose-transporters inhibitors and glucagon-like-peptide receptor agonist compared with monotherapy improves long-term survival: A real-world registry

Switching from retatrutide to tirzepatide This direction is simpler because you are removing a receptor pathway rather than adding one: Stop retatrutide and allow 1-2 weeks washout Start tirzepatide at 2.5 mg per standard protocol Escalate normally every 4 weeks Expect potentially faster tolerance since your GLP-1 and GIP receptors already have exposure history Some researchers report smoother GI tolerance when switching from a triple to a dual agonist, which makes pharmacological sense

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Obesity , 28 (6), 10501061