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Metanx was administered to 15 week old ZDF and ZDF lean rats at either 4.87 mgkg -1d -1 (the dose used in clinical practice) or 24.35 mgkg -1d -1, 2 times a day, for 4 weeks

Participants who were pregnant or breastfeeding or treated with nebulized NAC, newly prescribed mucoactive drugs, or subjected to changes in mucoactive drugs dosage within 4 weeks of treatment, and those with a history of hypersensitivity to NAC or contraindications for NAC, were excluded

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A more recent 2008 study 44 revealed that the levels of oxalate, a marker for vitamin B 6 deficiency, were elevated in the amniotic fluid of mothers carrying fetuses with DS