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211-214 Although letrozole is not FDA approved for the treatment of infertility, it appears to be the most effective treatment available and is frequently recommended as a first-line therapy, particularly in PCOS patients

In the present study, using a HEK cell-based model for GNE myopathy, the role of Insulin-like Growth Factor Receptor (IGF-1R) as cell survival receptor protein was studied to counter the apoptotic effect of non-functional GNE