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After four weeks, the diameter of micro vessels at the fingertips and thus microcirculation was significantly increased in 53.8% of the patients supplemented with Pycnogenol compared to 32% of subjects of the placebo group ( supplemented subjects compared to placebo-controlled people in the study

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It can influence other hormones such as cortisol and prolactin, potentially leading to broader systemic effects

This nonapeptide, first isolated from the cerebral venous blood of rabbits during sleep, has been shown to induce slow-wave sleep, modulate pain perception, and exhibit potential antioxidant and immunomodulatory properties