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Concurrent medication use: Patients on medications that influence mitochondrial or oxidative function, such as metformin, statins, or certain antidiabetics, may respond unpredictably when NAD+ is added

Semaglutide should not typically be combined with other medications that act on the same GLP-1 pathway, such as tirzepatide or other GLP-1 receptor agonists

As concerns other micronutrients, deficiencies of selenium and/or iron or zinc would increase the detrimental effect of iodine deficiency on thyroid function, and/or impair antioxidant defences of thyrocytes [54,55,56,57]

Also known as Sneddon-Champion syndrome and livedo reticularis racemosa, this disease can cause strokes and transient ischemic attacks (TIAs)