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NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

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Pharmacological targeting of IRE1 in anticancer approaches Gaining pharmacological control over IRE1 activities has been the focus of several anticancer drug development strategies, and these can be divided into two main approaches: (i) inhibiting IRE1 activity to impair adaptability of tumor cells to challenging tumor microenvironment and (ii) activating or hyperactivating IRE1 to initiate its RIDD that leads to cell death