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In addition to levels of AngIV in the brain, the test subjects underwent the Morris water maze test in order to measure the cognitive ability of APP/PS1 mice when administered Dihexa

The author's dual-acting compound addresses this issue: the NMDA receptor antagonist (MK-801) is only activated when the drug binds to and is internalized by the GLP-1 receptor

As well, since PPAR is also highly expressed in human hepatocytes (Kersten and Stienstra, 2017), it is reasonable to hypothesize that PPAR is involved in GLP-1 mediated lipid metabolism in the liver