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At a glance, the table underscores the throughline of this entire comparison: none of these three compounds substitutes for another, because each is anchored to a different level of biological activity cellular, mitochondrial, and endocrine, respectively

doi: 10.3389/fcell.2024.1376639 Received 25 January 2024 Accepted 10 June 2024 Published 02 July 2024 Volume 12 - 2024 Edited by Vandre Casagrande Figueiredo, Oakland University, United States Reviewed by Mengping Wei, Capital Medical University, China Ana Sevilla, University of Barcelona, Spain Updates Copyright 2024 Nussinov, Yavuz, Demirel, Arici, Jang and Tuncbag

We documented bioavailability and biologic effects of a stable salt of SAMe (1,4-butanedisulfonate salt, Nutramax Laboratories, Nutramax Laboratories, USA) in healthy cats, cats with asymptomatic cholangiohepatitis, and dogs with glucocorticoid-induced vacuolar hepatopathy

10.1016/j.bbagen.2012.10.005 Biochim Biophys Acta