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She also noted that phymatous rosacea, the skin thickening which often results in a bulbous appearance to the nose, in its earliest stages may be most noticeable on the ala, the area surrounding the nostrils, in patients of color

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Many of the technical problems have been solved (see the reviews cited below), and mass spectrometric methods are suited to routine screening of large numbers of samples of biological fluids from neonates, as they permit a considerable degree of automation, both of the analytical steps and of the gathering and interpretation of data, although there appears to be a need for a standardized methodology