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Our group has previously characterized three different subclasses of PE pathophysiology using a multiscale profiling approach that incorporated gestational parent/fetal clinical features and detailed placental profiling (molecular and histological)

Protein enrichment analysis showed that DPI and MitoQ single treatments induced a similar profile of downregulated peptides, affecting mainly members of the complex I of the mitochondrial respiratory chain and cell cycle/division proteins ( Supplementary Figures S3 , S4

Xaa amino acids are known as non-protein amino acids as they have not been associated with any specific codons

The Trx system was also associated with immune response to immunotherapy