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That's not real world [results]

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The pattern recurs across every endpoint category: an intermediate biomarker moves in the right direction, but the hard outcome the biomarker is supposed to predict does not follow

Tirzepatide once weekly for the treatment of obesity, The New England Journal of Medicine (2022) Weight loss outcomes associated with semaglutide treatment for patients with overweight or obesity, JAMA Network (2022) Semaglutide vs tirzepatide for weight loss in adults with overweight or obesity, JAMA Internal Medicine (2024) CVS Health announces it will drop Zepbound and prioritize coverage of Wegovy, Pharmacy Times (2025) Ozempic, DailyMed (2025) Zepbound, DailyMed (2025) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice