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4.1 Rheumatoid arthritis The pathogenic process of RA, a systemic autoimmune disease characterized by persistent synovitis, involves the activation of an aberrant immune response and the breakdown of immune system tolerance (131)

This is achieved by swapping the alanine amino acid at position 8 in the peptide backbone for alpha-aminoisobutyric acid (Aib), a modified amino acid that DPP-4 cannot recognize or cleave

The injection pen guide discusses alternative delivery methods that can reduce contamination risk, and the injections guide covers proper aseptic technique for syringe users