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Functionally, treated mice display enhanced treadmill endurance and a physiological profile resembling trained animals

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From meta-analyses including 3,092 patients from eight RCTs comparing pioglitazone in combination with any insulin-containing regimen compared to the same insulin regimen alone, pioglitazone confers a small advantage in terms of HbA1c in T2DM patients with previous inadequate glucose control but at the cost of increased hypoglycemia and weight gain [24]