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Examples include Tryptyr (acoltremon) , a first-in-class TRPM8 thermoreceptor agonist indicated for the treatment of the signs and symptoms of dry eye disease, and BRINSUPRI (brensocatib) , a first-in-class oral DPP1 inhibitor for non-cystic fibrosis bronchiectasis (NCFB), offering new treatment options for diseases that previously lacked effective therapies

Last year, the TGA issued a separate safety warning for rare but serious side effects linked with several GLP-1 RAs, including a correlation with increased risk of suicidal thoughts

Earlier this month, Holcomb called for a special session on inflation, which now appears likely to address abortion as well

Disproportionality analysis A sequential approach was adopted to systematically address major confounders: (1) An exploratory disproportionality approach comparing GLP-1RAs with all other drugs reported in the FAERS database, using venlafaxine as the positive control and empagliflozin/orlistat as the negative control