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Some patients and clinicians have explored combining ketogenic diets with prescription GLP-1 receptor agonist therapy, though this approach requires careful medical supervision

Semaglutide was administered orally in solution (SEMA) or encapsulated within reverse micelle lipid nanocapsules (SEMA-RM-LNC) (500 g/kg)

Clinical trials demonstrate that semaglutide typically achieves around 15% weight loss and liraglutide 58% over 68 weeks, even with minimal physical activity

The mechanism of action involves activation of both GIP and GLP-1 receptors, which are naturally occurring incretin hormones that play important roles in glucose homeostasis and appetite regulation