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Several were themselves regulated by AR, suggesting that previously unrecognized feedforward and feedback mechanisms exist
In particular, incomplete retrieval of grey literature and insufficient documentation of study-exclusion decisions could lead to overestimation of benefits or underdetection of harms, while the infrequent propagation of primary-study bias into meta-analytic models reduces confidence in the magnitude of pooled effects
There are arguments against the use of oral cobalamin in initiation of cobalamin therapy in severely deficient individuals who have poor absorption, especially due to pernicious anaemia
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