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In humans, intravenous infusion of a somatostatin analog, octreotide, 30 min prior to carbohydrate meal (Hycal) significantly impairs insulin, GLP-1, and GIP secretion in both lean and obese women, yet post-heparin LPL activity (contributions from adipose, skeletal and cardiac tissue) is unchanged 1.5 h post-peak insulin in lean and obese women (Ranganath et al., 1999)
These GLP-1 receptor agonist weight loss injections, originally developed for managing type 2 diabetes, not only promote significant weight loss but may also help with countless obesity-related health risks including pre-diabetes, heart disease, sleep apnea, and more
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