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Gamma glutamyltransferase and metabolic syndrome risk: a systematic review and dose-response meta-analysis

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This temporal pattern is consistent with the well-described phenomenon of GI adaptation to GLP-1 receptor activation, in which chronic receptor stimulation leads to desensitization of the vagal afferent pathways that mediate nausea and the enteric nervous system circuits that regulate gastric emptying and motility

Freezing irreversibly damages the peptide structure, reducing or eliminating efficacy