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Pyruvate kinase (PK) is considered a main regulator of energy homeostasis by the generation of glucose-derived pyruvate (45), but recently, cysteine catabolism and serine synthesis pathway (SSP) were considered the main supplier of pyruvate in cancer cells, as a way of overcoming the lack of PK expression (46)

In hippocampal cultures, DSIP upregulates BDNF and CREB phosphorylation, aiding neuroprotection studies

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