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Various factors may have contributed to these mixed results, including participant heterogeneity, compliance issues, and the aggressive placebo response often seen in obesity trials where lifestyle modification is encouraged

Lilly recognizes the potential here: a therapy like this could maintain strength and metabolic health during weight reduction, particularly for seniors or those prone to muscle atrophy

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While most patients return to their baseline state, individual responses vary, and some may experience more pronounced hunger or cravings during the adjustment period