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This weight loss connection helps explain why GLP-1 medications, originally developed for diabetes management and later approved for weight loss, are showing promising results for cholesterol management

Key factors include LED power, microchannel depth, the number and diameter of apertures, the gap between them, and the tilting angle of the cones

However, the action of GLP-1 is glucose-dependent and blood glucose is only lowered by GLP-1 if concentrations are above fasting levels [40, 41]

The PI3K/Akt pathway The first major downstream branch is the phosphatidylinositol-3-kinase (PI3K)/Akt (protein kinase B) pathway