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As the disease progresses, patients will likely require adjustments in their symptomatic medication regimens, potentially confounding the assessment of disease-modifying effects and requiring larger and longer studies

How We Evaluated These Programs Before naming the three, here are the four dimensions that mattered

The addition of GIP receptor activation was elegant in its simplicity and delivered tangible results

Semaglutide works through an entirely different mechanism: it activates GLP-1 receptors in the pancreas, gut, and brain to slow stomach emptying, enhance insulin secretion, and reduce hunger signaling