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Less Common but More Serious Risks Although uncommon, semaglutide may be associated with: Pancreatitis Gallbladder problems Kidney complications related to dehydration Changes in blood sugar levels Possible risk of thyroid C-cell tumors (observed in animal studies) Semaglutide is not recommended for individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Monitor patients on oral medications dependent on threshold concentrations for efficacy and those with a narrow therapeutic index (e.g., warfarin) when concomitantly administered with ZEPBOUND

This could include compounded medications prepared by specialized pharmacies