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Jha JC, Gray SP, Barit D, Okabe J, El-Osta A, Namikoshi T, Thallas-Bonke V, Wingler K, Szyndralewiez C, Heitz F, Touyz RM, Cooper ME, Schmidt HH, Jandeleit-Dahm KA (2014) Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy

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These findings suggest that direct and indirect lactylation coexist rather than exclude each other, and the dominant pathway likely depends on protein expression patterns in brain cells (Hagihara et al., 2021

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