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HSCs are activated by such factors as ROS, lipid peroxidation products (MDA and HNE), and TGF- released when adjacent cells including hepatocyte, Kupffer cells, and endothelial cells are injured

doi:10.1038/nature05859 Torrance CJ, Agrawal V, Vogelstein B, Kinzler KW (2001) Use of isogenic human cancer cells for high-throughput screening and drug discovery