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Semaglutide works as a GLP-1 receptor agonist, while Tirzepatide acts on both GIP and GLP-1 pathways
McIntyre RS, Rasgon N, Goldberg J, Wong S, Le GH, Mansur RB, Rosenblat JD, Teopiz KM, Stahl SM (2025) The effect of glucagon-like peptide-1 and glucose dependent insulinotropic polypeptide receptor agonists on neurogenesis, differentiation, and plasticity (Neuro-GDP): potential mechanistically informed therapeutics in the treatment and prevention of mental disorders
Like Zepbound, it targets both GLP-1 and GIP hormones
Although the detrimental effect of GLP-1 agonists have remained unclear with suggestions of increased risk of some cancers, recent reports in fact suggest a reduced risk of colorectal cancer (CRC)
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