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Collectively, limited evidence suggests that complement activation through redox pathways may have a more important role in cell and tissue damage in severe coronavirus infections rather than a major regulatory role in replication of coronaviruses

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In these studies, the beneficial effect of riboflavin supplementation (Reference Yu, Morimoto and Yu32,Reference Jiang, Chen and Liu33,Reference Peraza, Guzmn and Brizuela45) and the deleterious effect of its deficiency (Reference Jiang, Chen and Liu33,Reference Chen, Feng and Jiang35) on ROS levels in different tissues have been indicated

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