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doi:10.2460/javma.20.08.0462

The medication also produces modest reductions in systolic blood pressure (approximately 35 mmHg), reducing strain on the heart muscle and vascular system

Moreover, it reduces free radical production by suppressing cytochrome P450 enzyme activity.16 Growing evidence indicates that melatonin exerts significant protective effects on reproductive tissues through its potent antioxidant and anti-apoptotic properties.17-19 Experimental studies in both female and male models have shown that melatonin reduces oxidative stress markers, preserves follicular and testicular structure, and ameliorates apoptosis-related damage.18 In this study, the potential protective effects of Mel and GSH were investigated against CARB-induced ovarian damage in rats

Malagrino, F., Zuhra, K., Mascolo, L., Mastronicola, D., Vicente, J