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Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu 2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death

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This effect of GLP-1(2836) was independent of the known GLP-1R and was mediated by a mechanism involving mitochondrial MTP and intracellular sAC in caSMCs and caECs but not CMs

While short-acting versions like daily injections may better control postprandial glucose levels, they have largely been replaced by long-acting alternatives such as semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro and Zepbound), which only require weekly injections