When metformin must be discontinued, consultation with endocrinology or nephrology can help optimize the medication regimen, often combining SGLT2 inhibitors and GLP-1 agonists for maximal kidney and cardiovascular protection
For the study, researchers randomly assigned roughly 1,700 adults with type 2 diabetes to take one of two doses of the new GLP-1 pill, orforglipron, or one of two doses of oral semaglutide
Cleveland Clinic highlights fiber as useful for constipation that can happen on GLP-1 medications
Exclusion criteria were as follows: type 1 diabetes or positivity for anti-glutamic acid decarboxylase autoantibodies, secondary forms of diabetes, acute metabolic complications, liver disease, renal dysfunction or patients under anticoagulant treatment, previous bariatric surgery, congenital or acquired abnormalities of the digestive tract, pregnancy, nursing or desired pregnancy in the 12 months following inclusion, and corticoid use by oral or intravenous route for more than 14 consecutive days in the last 3 months
